Hylenex (Hyaluronidase) Injection After-Care

Hylenex (Hyaluronidase) is an enzyme that breaks down hyaluronic acid (HA) fillers, but it can also break down naturally occurring HA present in the body. The results can be unpredictable and the effect dramatic with possible loss of volume and some skin laxity. Although some of the effects can be immediate, it can take up to 2 weeks for the final results to be seen and the procedure may need to be repeated.

Hylenex administration can result in anaphylaxis (a severe allergic reaction) which in itself is life-threatening and requires immediate medical attention. Symptoms of a severe allergic reaction can include shortness of breath, wheezing, coughing, difficulty swallowing, swelling of the tongue, eyelids, lips, hoarseness of the voice, stomach pain, nausea, or diarrhea.

If you have any of the above symptoms, please report to your nearest Emergency Department or call 911 for an ambulance.

After the procedure, some other common injection-related reactions might occur. These reactions include redness, swelling, pain, itching, bruising, and tenderness at the injection site. They have generally been described as mild to moderate and typically resolve spontaneously after a few days after injection. Bruising may occasionally be more significant.

If you have any concerns following treatment, do not hesitate to contact us by phone during business hours. If the call is outside of normal business hours, please leave a message and we will get back to you upon checking messages during normal business hours. If you are having side effects that need immediate medical attention and it is outside of normal business hours, please go to the emergency room for immediate treatment.